UNIT 1:
mechanisms of solute solvent interactions
diffusion principles in biological systems
solubility of liquids in liquids, Binary solutions
quantitative approach to the factors influencing solubility of drugs
ideal solutions, Raoult’s law, real solutions.
ideal solubility parameters
Partially miscible liquids, Critical solution temperature and applications.
Distribution law, its limitations and applications.
UNIT 2:
States of matter and properties of matter
Physiochemical properties of drug molecules
UNIT 3:
Liquid interface, Surface and interfacial tensions
Adsorption at liquid interfaces
Adsorption at solid interface
Measurement of surface and interfacial tensions
UNIT 4:
Introduction, Classification of Complexation, Applications,
methods of analysis- complexation
Protein binding, Complexation and drug action, crystalline structures of complexes and thermodynamic treatment of stability constants.
UNIT 5:
pH determination (electrometric and calorimetric)
applications of buffers, buffer equation,
buffers in pharmaceutical and biological systems
buffered isotonic solutions
