Haemodynamic aspects of total heart – Lung bypass Perfusion flow pressure and resistance distribution of blood flow among various vascular beds. Metabolic aspects of total heart – Lung bypass Oxygen need and perfusion flow requirementsPerfusion flow and oxygen uptake Acid-base balance Electrolyte and water balance Oxygen toxicity

Effects of perfusion on organs Brain, heart, lungs, kidney liver and spleen area and other organs Control of adequacy of perfusion The ideal perfusion Monitoring devices Techniques of control

Hematological problems Blood prime Priming solutions Control of Effects of various priming solution on RBC trauma Induced cardiac arrest and myocardial protection Physiological principles of including cardiac arrest, morphology, function and metabolism of the arrested heart Cardioplegia – Cold blood, potassium and Modified cold prime cardioplegia

Hypothermia Blood stream cooling nerves peripheral cooling modes of blood stream cooling heart and circulation at low termprature Assisted circulation Circulatory support metabolic support by partial heart lung bypass. Effects of partial heart-lung bypass on organs.

Biomedicus pump LV assist devices – LVAD, RVAD, BIVAD Intra-aortic balloon pump – IABP Autotransfusion, cell saver.